Therapeutic Implications of the Immunoscore in Patients with Colorectal Cancer.

ABSTRACT: Four decades were needed to progress from the first demonstration of the independent prognostic value of lymphocytes infiltration in rectal cancers to the first recommendation from the international guidelines for the use of a standardized immune assay, namely the "Immunoscore" (IS), to accurately prognosticate colon cancers beyond the TNM-system. The standardization process included not only the IS conceptualization, development, fine-tuning, and validation by a large international consortium, but also a demonstration of the robustness and reproducibility across the world and testing of international norms and their effects on the IS. This is the first step of a major change of paradigm that now perceives cancer as the result of contradicting driving forces, i.e., the tumor expansion and

SUBMITTER: El Sissy C 

PROVIDER: S-EPMC8001764 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature