Microglia Diversity in Healthy and Diseased Brain: Insights from Single-Cell Omics.

ABSTRACT: Microglia are the resident immune cells of the central nervous system (CNS) that have distinct ontogeny from other tissue macrophages and play a pivotal role in health and disease. Microglia rapidly react to the changes in their microenvironment. This plasticity is attributed to the ability of microglia to adapt a context-specific phenotype. Numerous gene expression profiling studies of immunosorted CNS immune cells did not permit a clear dissection of their phenotypes, particularly in diseases when peripheral cells of the immune system come to play. Only recent advances in single-cell technologies allowed studying microglia at high resolution and revealed a spectrum of discrete states both under homeostatic and pathological conditions. Single-cell technologies such as single-cell RNA sequ

SUBMITTER: Ochocka N 

PROVIDER: S-EPMC8002227 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature