Signaling Pathways in Cancer: Therapeutic Targets, Combinatorial Treatments, and New Developments.

ABSTRACT: Molecular alterations in cancer genes and associated signaling pathways are used to inform new treatments for precision medicine in cancer. Small molecule inhibitors and monoclonal antibodies directed at relevant cancer-related proteins have been instrumental in delivering successful treatments of some blood malignancies (e.g., imatinib with chronic myelogenous leukemia (CML)) and solid tumors (e.g., tamoxifen with ER positive breast cancer and trastuzumab for HER2-positive breast cancer). However, inherent limitations such as drug toxicity, as well as acquisition of de novo or acquired mechanisms of resistance, still cause treatment failure. Here we provide an up-to-date review of the successes and limitations of current targeted therapies for cancer treatment and highlight how recent tec

SUBMITTER: Yip HYK 

PROVIDER: S-EPMC8002322 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature