Heterogeneity in Signaling Pathway Activity within Primary and between Primary and Metastatic Breast Cancer.

ABSTRACT: Targeted therapy aims to block tumor-driving signaling pathways and is generally based on analysis of one primary tumor (PT) biopsy. Tumor heterogeneity within PT and between PT and metastatic breast lesions may, however, impact the effect of a chosen therapy. Whereas studies are available that investigate genetic heterogeneity, we present results on phenotypic heterogeneity by analyzing the variation in the functional activity of signal transduction pathways, using an earlier developed platform to measure such activity from mRNA measurements of pathways' direct target genes. Statistical analysis comparing macro-scale variation in pathway activity on up to five spatially distributed PT tissue blocks (n = 35), to micro-scale variation in activity on four adjacent samples of a single PT tiss

SUBMITTER: Inda MA 

PROVIDER: S-EPMC8002348 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature