Effects of Low Dose Space Radiation Exposures on the Splenic Metabolome.

ABSTRACT: Future space missions will include a return to the Moon and long duration deep space roundtrip missions to Mars. Leaving the protection that Low Earth Orbit provides will unavoidably expose astronauts to higher cumulative doses of space radiation, in addition to other stressors, e.g., microgravity. Immune regulation is known to be impacted by both radiation and spaceflight and it remains to be seen whether prolonged effects that will be encountered in deep space can have an adverse impact on health. In this study, we investigated the effects in the overall metabolism of three different low dose radiation exposures (γ-rays, ¹⁶O, and ⁵⁶Fe) in spleens from male C57BL/6 mice at 1, 2, and 4 months after exposure. Forty metabolites were identified with significant enrichmen

SUBMITTER: Laiakis EC 

PROVIDER: S-EPMC8002539 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature