Does Saccharomyces cerevisiae Require Specific Post-Translational Silencing against Leaky Translation of Hac1up?

ABSTRACT: HAC1 encodes a key transcription factor that transmits the unfolded protein response (UPR) from the endoplasmic reticulum (ER) to the nucleus and regulates downstream UPR genes in Saccharomyces cerevisiae. In response to the accumulation of unfolded proteins in the ER, Ire1p oligomers splice HAC1 pre-mRNA (HAC1^u) via a non-conventional process and allow the spliced HAC1 (HAC1ⁱ) to be translated efficiently. However, leaky splicing and translation of HAC1^u may occur in non-UPR cells to induce undesirable UPR. To control accidental UPR activation, multiple fail-safe mechanisms have been proposed to prevent leaky HAC1 splicing and translation and to facilitate rapid degradation of translated Hac1^u

SUBMITTER: Tehfe A 

PROVIDER: S-EPMC8002603 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature