Hepatitis B Virus Genotype Study in West Africa Reveals an Expanding Clade of Subgenotype A4.

ABSTRACT: Hepatitis B virus (HBV) classification comprises up to 10 genotypes with specific geographical distribution worldwide, further subdivided into 40 subgenotypes, which have different impacts on liver disease outcome. Though extensively studied, the classification of subgenotype A sequences remains ambiguous. This study aimed to characterize HBV isolates from West African patients and propose a more advanced classification of subgenotype A. Fourteen HBV full-length genome sequences isolated from patients from The Gambia and Senegal were obtained and phylogenetically analyzed. Phylogenetic analysis of HBV genotype A sequences isolated from Senegalese and Gambian patients exhibited separate clusters from the other known and confirmed subgenotypes A (A1, A2, A6). Most of the sequences (10/14) cl

SUBMITTER: Toye RM 

PROVIDER: S-EPMC8002614 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature