Genetic Markers of Genome Rearrangements in Helicobacter pylori.

ABSTRACT: Helicobacter pylori exhibits a diverse genomic structure with high mutation and recombination rates. Various genetic elements function as drivers of this genomic diversity including genome rearrangements. Identifying the association of these elements with rearrangements can pave the way to understand its genome evolution. We analyzed the order of orthologous genes among 72 publicly available complete genomes to identify large genome rearrangements, and rearrangement breakpoints were compared with the positions of insertion sequences, genomic islands, and restriction modification genes. Comparison of the shared inversions revealed the conserved genomic elements across strains from different geographical locations. Some were region-specific and others were global, indicating that high

SUBMITTER: Noureen M 

PROVIDER: S-EPMC8002640 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature