Current Perspectives on Taxanes: Focus on Their Bioactivity, Delivery and Combination Therapy.

ABSTRACT: Taxanes, mainly paclitaxel and docetaxel, the microtubule stabilizers, have been well known for being the first-line therapy for breast cancer for more than the last thirty years. Moreover, they have been also used for the treatment of ovarian, hormone-refractory prostate, head and neck, and non-small cell lung carcinomas. Even though paclitaxel and docetaxel significantly enhance the overall survival rate of cancer patients, there are some limitations of their use, such as very poor water solubility and the occurrence of severe side effects. However, this is what pushes the research on these microtubule-stabilizing agents further and yields novel taxane derivatives with significantly improved properties. Therefore, this review article brings recent advances reported in taxane research mai

SUBMITTER: Skubnik J 

PROVIDER: S-EPMC8002726 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature