Discovery of Screening Biomarkers for Major Depressive Disorder in Remission by Proteomic Approach.

ABSTRACT: Major depressive disorder (MDD) is a common disorder involving depressive mood and decreased motivation. Due to its high heterogeneity, novel biomarkers are required to diagnose MDD. In this study, a proteomic method was used to identify a new MDD biomarker. Using sequential window acquisition of all theoretical mass spectra acquisitions and multiple reaction monitoring analysis via mass spectrometry, relative and absolute quantification of proteins in the sera was performed. The results of the relative quantitation by sequential window acquisition for all theoretical mass spectra data showed that seven proteins were significantly differently expressed between MDD patients and other patients with remission status. However, absolute quantification by multiple reaction monitoring analysis id

SUBMITTER: Choi H 

PROVIDER: S-EPMC8002827 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature