Synthesis, Molecular Docking Studies and In Silico ADMET Screening of New Heterocycles Linked Thiazole Conjugates as Potent Anti-Hepatic Cancer Agents.

ABSTRACT: Thiazoles are important scaffolds in organic chemistry. Biosynthesis of thiazoles is considered to be an excellent target for the design of novel classes of therapeutic agents. In this study, a new series of 2-ethylidenehydrazono-5-arylazothiazoles 5a-d and 2-ethylidenehydrazono-5-arylazo- thiazolones 8a-d were synthesized via the cyclocondensation reaction of the appropriate hydrazonyl halides 4a-d and 7a-d with ethylidene thiosemicarbazide 3, respectively. Furthermore, the thiosemicarbazide derivative 3 was reacted with different bromoacetyl compounds 10-12 to afford the respective thiazole derivatives 13-15. Chemical composition of the novel derivatives was established on bases of their spectral data (FTIR, 1H-NMR, 13C-NMR and mass spectrometry) and microanalytical data. The newly synth

SUBMITTER: Rashdan HRM 

PROVIDER: S-EPMC8003218 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature