Phylogenomic Evidence of Reinfection and Persistence of SARS-CoV-2: First Report from Colombia.

ABSTRACT: The continuing evolution of SARS-CoV-2 and the emergence of novel variants have raised concerns about possible reinfection events and potential changes in the coronavirus disease 2019 (COVID-19) transmission dynamics. Utilizing Oxford Nanopore technologies, we sequenced paired samples of three patients with positive RT-PCR results in a 1-2-month window period, and subsequent phylogenetics and genetic polymorphism analysis of these genomes was performed. Herein, we report, for the first time, genomic evidence of one case of reinfection in Colombia, exhibiting different SARS-CoV-2 lineage classifications between samples (B.1 and B.1.1.269). Furthermore, we report two cases of possible viral persistence, highlighting the importance of deepening our understanding on the evolutionary intra-host

SUBMITTER: Ramirez JD 

PROVIDER: S-EPMC8003345 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature