The Interactome between Metabolism and Gene Mutations in Myeloid Malignancies.

ABSTRACT: The study of metabolic deregulation in myeloid malignancies has led to the investigation of metabolic-targeted therapies considering that cells undergoing leukemic transformation have excessive energy demands for growth and proliferation. However, the most difficult challenge in agents targeting metabolism is to determine a window of therapeutic opportunities between normal and neoplastic cells, considering that all or most of the metabolic pathways important for cancer ontogeny may also regulate physiological cell functions. Targeted therapies have used the properties of leukemic cells to produce altered metabolic products when mutated. This is the case of IDH1/2 mutations generating the abnormal conversion of α-ketoglutarate (KG) to 2-hydroxyglutarate, an oncometabolite inh

SUBMITTER: Gurnari C 

PROVIDER: S-EPMC8003366 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature