Effects of Combined Vitamin K2 and Vitamin D3 Supplementation on Na[¹⁸F]F PET/MRI in Patients with Carotid Artery Disease: The INTRICATE Rationale and Trial Design.

ABSTRACT: INTRICATE is a prospective double-blind placebo-controlled feasibility study, assessing the influence of combined vitamin K2 and vitamin D3 supplementation on micro-calcification in carotid artery disease as imaged by hybrid Sodium [¹⁸F]Fluoride (Na[¹⁸F]F) positron emission tomography (PET)/ magnetic resonance imaging (MRI). Arterial calcification is an actively regulated process and results from the imbalance between calcification promoting and inhibiting factors. Considering the recent advancements in medical imaging, ultrasound (US), PET/MRI, and computed tomography (CT) can be used for the selection and stratification of patients with atherosclerosis. Fifty-two subjects with asymptomatic carotid artery disease on at least one side of the neck will be included in t

SUBMITTER: Florea A 

PROVIDER: S-EPMC8003489 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature