Roma Socioeconomic Status Has a Higher Impact on Smoking Behaviour than Genetic Susceptibility.

ABSTRACT: It is a matter of speculation whether the high prevalence of smoking among Hungarian Roma (HR) is related to genetic, gene-environmental interactions or cultural factors. Our aim is to compare the genetic susceptibility and possible effects of determinants associated with smoking behaviours in the Hungarian general (HG) and Roma populations. A complex health survey including three pillars (questionnaire, physical and laboratory examinations) was carried out (N_HG = 412 and N_HR = 402). Risk allele frequencies of ten single-nucleotide polymorphisms (SNPs) were compared, and their combined effect was estimated by computing unweighted and weighted genetic risk scores (GRS, wGRS). The effects of genetic and environmental factors were investigated in regression analyses afte

SUBMITTER: Merzah M 

PROVIDER: S-EPMC8003628 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature