The Phosin PptA Plays a Negative Role in the Regulation of Antibiotic Production in Streptomyces lividans.

ABSTRACT: In Streptomyces, antibiotic biosynthesis is triggered in phosphate limitation that is usually correlated with energetic stress. Polyphosphates constitute an important reservoir of phosphate and energy and a better understanding of their role in the regulation of antibiotic biosynthesis is of crucial importance. We previously characterized a gene, SLI_4384/ppk, encoding a polyphosphate kinase, whose disruption greatly enhanced the weak antibiotic production of Streptomyces lividans. In the condition of energetic stress, Ppk utilizes polyP as phosphate and energy donor, to generate ATP from ADP. In this paper, we established that ppk is co-transcribed with its two downstream genes, SLI_4383, encoding a phosin called PptA possessing a CHAD domain constitutin

SUBMITTER: Shikura N 

PROVIDER: S-EPMC8003754 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature