Vitamin D and Allergy Susceptibility during Gestation and Early Life.

ABSTRACT: Worldwide, the prevalence of allergies in young children, but also vitamin D deficiency during pregnancy and in newborns is rising. Vitamin D modulates the development and activity of the immune system and a low vitamin D status during pregnancy and in early life might be associated with an increased risk to develop an allergy during early childhood. This review studies the effects of vitamin D during gestation and early life, on allergy susceptibility in infants. The bioactive form of vitamin D, 1,25(OH)2D, inhibits maturation and results in immature dendritic cells that cause a decreased differentiation of naive T cells into effector T cells. Nevertheless, the development of regulatory T cells and the production of interleukin-10 was increased. Consequently, a more tolerogenic immune res

SUBMITTER: Briceno Noriega D 

PROVIDER: S-EPMC8003945 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature