Every Detail Matters. That Is, How the Interaction between Gα Proteins and Membrane Affects Their Function.

ABSTRACT: In highly organized multicellular organisms such as humans, the functions of an individual cell are dependent on signal transduction through G protein-coupled receptors (GPCRs) and subsequently heterotrimeric G proteins. As most of the elements belonging to the signal transduction system are bound to lipid membranes, researchers are showing increasing interest in studying the accompanying protein-lipid interactions, which have been demonstrated to not only provide the environment but also regulate proper and efficient signal transduction. The mode of interaction between the cell membrane and G proteins is well known. Despite this, the recognition mechanisms at the molecular level and how the individual G protein-membrane attachment signals are interrelated in the process of the complex con

SUBMITTER: Polit A 

PROVIDER: S-EPMC8003949 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature