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New Polyketides from the Antarctic Fungus Pseudogymnoascus sp. HSX2#-11.

ABSTRACT: The species Pseudogymnoascus is known as a psychrophilic pathogenic fungus with a ubiquitous distribution in Antarctica. Meanwhile, the study of its secondary metabolites is infrequent. Systematic research of the metabolites of the fungus Pseudogymnoascus sp. HSX2#-11, guided by the method of molecular networking, led to the isolation of one novel polyketide, pseudophenone A (1), along with six known analogs (2-7). The structure of the new compound was elucidated by extensive spectroscopic investigation and single-crystal X-ray diffraction. Pseudophenone A (1) is a dimer of diphenyl ketone and diphenyl ether, and there is only one analog of 1 to the best of our knowledge. Compounds 1 and 2 exhibited antibacterial activities against a panel of strains. This is the first time to use molecular networking to study the metabolic profiles of Antarctica fungi.

SUBMITTER: Shi T

PROVIDER: S-EPMC8004129 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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New Polyketides from the Antarctic Fungus Pseudogymnoascus sp. HSX2#-11.

Shi Ting T Yu Yan-Yan YY Dai Jia-Jia JJ Zhang Yi-Ting YT Hu Wen-Peng WP Zheng Li L Shi Da-Yong DY

Marine drugs 20210322 3

The species Pseudogymnoascus is known as a psychrophilic pathogenic fungus with a ubiquitous distribution in Antarctica. Meanwhile, the study of its secondary metabolites is infrequent. Systematic research of the metabolites of the fungus Pseudogymnoascus sp. HSX2#-11, guided by the method of molecular networking, led to the isolation of one novel polyketide, pseudophenone A (1), along with six known analogs (2-7). The structure of the new compound was elucidat ...[more]

PMID: 33809861

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