A Resource for the Network Representation of Cell Perturbations Caused by SARS-CoV-2 Infection.

ABSTRACT: The coronavirus disease 2019 (COVID-19) pandemic has caused more than 2.3 million casualties worldwide and the lack of effective treatments is a major health concern. The development of targeted drugs is held back due to a limited understanding of the molecular mechanisms underlying the perturbation of cell physiology observed after viral infection. Recently, several approaches, aimed at identifying cellular proteins that may contribute to COVID-19 pathology, have been reported. Albeit valuable, this information offers limited mechanistic insight as these efforts have produced long lists of cellular proteins, the majority of which are not annotated to any cellular pathway. We have embarked in a project aimed at bridging this mechanistic gap by developing a new bioinformatic approach to est

SUBMITTER: Perfetto L 

PROVIDER: S-EPMC8004236 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature