Hepatitis C Viral Replication Complex.
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ABSTRACT:
SUBMITTER: Li HC
PROVIDER: S-EPMC8004249 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Publications
Hepatitis C Viral Replication Complex.
Li Hui-Chun HC Yang Chee-Hing CH Lo Shih-Yen SY
Viruses 20210322 3
The life cycle of the hepatitis C virus (HCV) can be divided into several stages, including viral entry, protein translation, RNA replication, viral assembly, and release. HCV genomic RNA replication occurs in the replication organelles (RO) and is tightly linked to ER membrane alterations containing replication complexes (proteins NS3 to NS5B). The amplification of HCV genomic RNA could be regulated by the RO biogenesis, the viral RNA structure (i.e., cis-acting replication elements), and both ...[more]
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