Diet and gut microbiome interactions of relevance for symptoms in irritable bowel syndrome.

ABSTRACT:

Background

While several studies have documented associations between dietary habits and microbiota composition and function in healthy individuals, no study explored these associations in patients with irritable bowel syndrome (IBS), and especially with symptoms.

Methods

Here, we used a novel approach that combined data from a 4-day food diary, integrated into a food tree, together with gut microbiota (shotgun metagenomic) for individuals with IBS (N = 149) and healthy controls (N = 52). Paired microbiota and food-based trees allowed us to detect new associations between subspecies and diet. Combining co-inertia analysis and linear regression models, exhaled gas levels and symptom severity could be predicted from metagenomic and dietary data.

Results

We showed that i

SUBMITTER: Tap J 

PROVIDER: S-EPMC8004395 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature