Identification and validation of a five-gene prognostic signature for hepatocellular carcinoma.

ABSTRACT:

Background

ARID1A is a commonly mutated tumor suppressor gene found in all human cancer types, but its clinical significance, oncogenic functions, and relevant mechanisms in hepatocellular carcinoma (HCC) are not well understood.

Objective

We aimed to improving the prognosis risk classification of HCC from the perspective of ARID1A mutations.

Materials and methods

We examined the interaction between ARID1A mutations and the overall survival via Kaplan-Meier survival analysis. We used gene set enrichment analysis (GSEA) to elucidate the influence of ARID1A mutations on signaling pathways. A prognostic model was constructed using LASSO and multivariate Cox regression analyses. A receiver operating characteristic (ROC) curve was used to estimate the performance and accur

SUBMITTER: Yang H 

PROVIDER: S-EPMC8004398 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature