High-dose rapamycin exerts a temporary impact on T. reesei RUT-C30 through gene trFKBP12.

ABSTRACT:

Background

Knowledge with respect to regulatory systems for cellulase production is prerequisite for exploitation of such regulatory networks to increase cellulase production, improve fermentation efficiency and reduce the relevant production cost. The target of rapamycin (TOR) signaling pathway is considered as a central signaling hub coordinating eukaryotic cell growth and metabolism with environmental inputs. However, how and to what extent the TOR signaling pathway and rapamycin are involved in cellulase production remain elusive.

Result

At the early fermentation stage, high-dose rapamycin (100 μM) caused a temporary inhibition effect on cellulase production, cell growth and sporulation of Trichoderma reesei RUT-C30 independently of the carbon sources, and specifically c

SUBMITTER: Pang AP 

PROVIDER: S-EPMC8004424 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature