Rapid systemic surge of IL-33 after severe human trauma: a prospective observational study.

ABSTRACT:

Background

Alarmins are considered proximal mediators of the immune response after tissue injury. Understanding their biology could pave the way for development of new therapeutic targets and biomarkers in human disease, including multiple trauma. In this study we explored high-resolution concentration kinetics of the alarmin interleukin-33 (IL-33) early after human trauma.

Methods

Plasma samples were serially collected from 136 trauma patients immediately after hospital admission, 2, 4, 6, and 8 h thereafter, and every morning in the ICU. Levels of IL-33 and its decoy receptor sST2 were measured by immunoassays.

Results

We observed a rapid and transient surge of IL-33 in a subset of critically injured patients. These patients had more widespread tissue injuries and a

SUBMITTER: Sundnes O 

PROVIDER: S-EPMC8004436 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature