Ontology highlight
ABSTRACT:
SUBMITTER: Loy K
PROVIDER: S-EPMC8004489 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Loy Kristina K Fourneau Julie J Meng Ning N Denecke Carmen C Locatelli Giuseppe G Bareyre Florence M FM
Cellular and molecular life sciences : CMLS 20201030 6
Descending serotonergic (5-HT) projections originating from the raphe nuclei form an important input to the spinal cord that control basic locomotion. The molecular signals that control this projection pattern are currently unknown. Here, we identify Semaphorin7A (Sema7A) as a critical cue that restricts serotonergic innervation in the spinal cord. Sema7A deficient mice show a marked increase in serotonergic fiber density in all layers of the spinal cord while the density of neurons expressing t ...[more]