Inhibition of Nuclear Pore Complex Formation Selectively Induces Cancer Cell Death.

ABSTRACT: Nuclear pore complexes (NPC) are the central mediators of nucleocytoplasmic transport. Increasing evidence shows that many cancer cells have increased numbers of NPCs and become addicted to the nuclear transport machinery. How reducing NPC numbers affects the physiology of normal and cancer cells and whether it could be exploited for cancer therapies has not been investigated. We report that inhibition of NPC formation, a process mostly restricted to proliferating cells, causes selective cancer cell death, prevents tumor growth, and induces tumor regression. Although cancer cells die in response to NPC assembly inhibition, normal cells undergo a reversible cell-cycle arrest that allows them to survive. Mechanistically, reducing NPC numbers results in multiple alterations contributing to ca

SUBMITTER: Sakuma S 

PROVIDER: S-EPMC8004544 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature