Bioinformatic Analysis of Genome-Predicted Bat Cathelicidins.

ABSTRACT: Bats are unique in their potential to serve as reservoir hosts for intracellular pathogens. Recently, the impact of COVID-19 has relegated bats from biomedical darkness to the frontline of public health as bats are the natural reservoir of many viruses, including SARS-Cov-2. Many bat genomes have been sequenced recently, and sequences coding for antimicrobial peptides are available in the public databases. Here we provide a structural analysis of genome-predicted bat cathelicidins as components of their innate immunity. A total of 32 unique protein sequences were retrieved from the NCBI database. Interestingly, some bat species contained more than one cathelicidin. We examined the conserved cysteines within the cathelin-like domain and the peptide portion of each sequence and revealed phyl

SUBMITTER: Perez de la Lastra JM 

PROVIDER: S-EPMC8004601 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature