A Comparative in Silico Analysis of CD24's Prognostic Value in Human and Canine Prostate Cancer.

ABSTRACT: CD24 is a cell surface molecule anchored by glycosyl-phosphatidyl-inositol and expressed by different human cancers, including prostate cancer (PC). Some studies have demonstrated that CD24 expression is associated with poor patient outcome; however, few studies have investigated CD24 expression in spontaneous animal models of human PC, such as canine PC. This study aimed to evaluate the expression of CD24 in human PC using the in silico analysis of the data obtained from The Cancer Genome Atlas (TCGA) and comparing it with the previously published prostatic canine transcriptome data. In addition, CD24 expression was confirmed by immunohistochemistry in an independent cohort of canine prostatic samples and its prognostic significance assessed. The systematic review identified 10 publicatio

SUBMITTER: Leis-Filho AF 

PROVIDER: S-EPMC8004660 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature