Biodistribution and Pharmacokinectics of Liposomes and Exosomes in a Mouse Model of Sepsis.

ABSTRACT: Exosomes have attracted considerable attention as drug delivery vehicles because their biological properties can be utilized for selective delivery of therapeutic cargoes to disease sites. In this context, analysis of the in vivo behaviors of exosomes in a diseased state is required to maximize their therapeutic potential as drug delivery vehicles. In this study, we investigated biodistribution and pharmacokinetics of HEK293T cell-derived exosomes and PEGylated liposomes, their synthetic counterparts, into healthy and sepsis mice. We found that biodistribution and pharmacokinetics of exosomes were significantly affected by pathophysiological conditions of sepsis compared to those of liposomes. In the sepsis mice, a substantial number of exosomes were found in the lung after intravenous inj

SUBMITTER: Mirzaaghasi A 

PROVIDER: S-EPMC8004782 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature