Identification of Bioactive Compounds from Marine Natural Products and Exploration of Structure-Activity Relationships (SAR).

ABSTRACT: Marine natural products (MNPs) have been an important and rich source for antimicrobial drug discovery and an effective alternative to control drug resistant infections. Herein, we report bioassay guided fractionation of marine extracts from sponges Lendenfeldia, Ircinia and Dysidea that led us to identify novel compounds with antimicrobial properties. Tertiary amines or quaternary amine salts: aniline 1, benzylamine 2, tertiary amine 3 and 4, and quaternary amine salt 5, along with three known compounds (6-8) were isolated from a crude extract and MeOH eluent marine extracts. The antibiotic activities of the compounds, and their isolation as natural products have not been reported before. Using tandem mass spectrometry (MS) an

SUBMITTER: Dinarvand M 

PROVIDER: S-EPMC8004798 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature