Conserved Structural Motifs of Two Distant IAV Subtypes in Genomic Segment 5 RNA.

ABSTRACT: The functionality of RNA is fully dependent on its structure. For the influenza A virus (IAV), there are confirmed structural motifs mediating processes which are important for the viral replication cycle, including genome assembly and viral packaging. Although the RNA of strains originating from distant IAV subtypes might fold differently, some structural motifs are conserved, and thus, are functionally important. Nowadays, NGS-based structure modeling is a source of new in vivo data helping to understand RNA biology. However, for accurate modeling of in vivo RNA structures, these high-throughput methods should be supported with other analyses facilitating data interpretation. In vitro RNA structural models complement such approaches and offer RNA structures based on experimental data obt

SUBMITTER: Michalak P 

PROVIDER: S-EPMC8004953 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature