Early detection of amyloid load using ¹⁸F-florbetaben PET.

ABSTRACT:

Background

A low amount and extent of Aβ deposition at early stages of Alzheimer's disease (AD) may limit the use of previously developed pathology-proven composite SUVR cutoffs. This study aims to characterize the population with earliest abnormal Aβ accumulation using ¹⁸F-florbetaben PET. Quantitative thresholds for the early (SUVR_early) and established (SUVR_estab) Aβ deposition were developed, and the topography of early Aβ deposition was assessed. Subsequently, Aβ accumulation over time, progression from mild cognitive impairment (MCI) to AD dementia, and tau deposition were assessed in subjects with early and established Aβ deposition.

Methods

The study population consisted of 686 subjects (n = 287 (cognitively normal healthy controls),

SUBMITTER: Bullich S 

PROVIDER: S-EPMC8005243 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature