Endogenous mitochondrial double-stranded RNA is not an activator of the type I interferon response in human pancreatic beta cells.

ABSTRACT:

Background

Type 1 diabetes (T1D) is an autoimmune disease characterized by the progressive destruction of pancreatic beta cells. Interferon-α (IFNα), an antiviral cytokine, is expressed in the pancreatic islets in early T1D, which may be secondary to viral infections. However, not all patients harboring a type I IFN signature present signals of viral infection, suggesting that this response might be initiated by other "danger signals". Accumulation of mitochondrial double-stranded RNA (mtdsRNA; a danger signal), secondary to silencing of members of the mitochondrial degradosome, PNPT1 and SUV3, has been described to activate the innate immune response.

Methods

To evaluate whether mtdsRNA represents a "danger signal" for pancreatic beta cells in the context of T1D, we silence

SUBMITTER: Coomans de Brachene A 

PROVIDER: S-EPMC8005246 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature