AP-2β is required for formation of the murine trabecular meshwork and Schlemm's canal.

ABSTRACT: Previously, we have shown that Tfap2b, the gene encoding transcription factor AP-2β, is needed for normal mouse eye development. Specifically, targeted loss of Tfap2b in neural crest cells (NCCs)¹ and their derivatives, particularly the periocular mesenchyme (POM), resulted in anterior segment defects affecting the cornea and angle tissue. These defects were further associated with an increase in intraocular pressure (IOP). The present study investigates the underlying changes in embryonic and postnatal POM cell development and differentiation caused by loss of AP-2β in the NCCs, particularly in the structures that control aqueous outflow, using Wnt1Cre^+/-; Tfap2b^-/lox; tdTomato^lox/+ mice (AP-2β neural crest cell knockout or AP-2β NCC KO). Toluid

SUBMITTER: Akula M 

PROVIDER: S-EPMC8005257 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature