The interplay between externalizing disorders polygenic risk scores and contextual factors on the development of marijuana use disorders.

ABSTRACT: Externalizing disorders have been extensively linked to substance use problems. However, less is known about whether genetic factors underpinning externalizing disorders and environmental features interact to predict substance use disorders (i.e., marijuana abuse and dependence) among urban African Americans. We examined whether polygenic risk scores (PRS) for conduct disorder (CD) and attention-deficit hyperactivity disorder (ADHD) interacted with contextual factors (i.e., parental monitoring, community disadvantage) to influence risk for marijuana use disorders in a sample of African American youth. Participants (N=1,050; 44.2% male) were initially recruited for an elementary school-based universal prevention trial in a Mid-Atlantic city and followed through age 20. Participants reported

SUBMITTER: Rabinowitz JA 

PROVIDER: S-EPMC8005265 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature