Cerebrovascular damage after midlife transient hypertension in non-transgenic and Alzheimer's disease rats.

ABSTRACT: Hypertension, including transient events, is a major risk factor for developing late-onset dementia and Alzheimer's disease (AD). Anti-hypertensive drugs facilitate restoration of normotension without amelioration of increased dementia risk suggesting that transient hypertensive insults cause irreversible damage. This study characterized the contribution of transient hypertension to sustained brain damage as a function of normal aging and AD. To model transient hypertension, we treated F344TgAD and non-transgenic littermate rats with L-NG-Nitroarginine methyl ester (L-NAME) for one month, ceased treatment and allowed for a month of normotensive recovery. We then examined the changes in the structure and function of the cerebrovasculature, integrity of white matter, and progression of AD pa

SUBMITTER: Lai AY 

PROVIDER: S-EPMC8005286 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature