Appetite disinhibition rather than hunger explains genetic effects on adult BMI trajectory.

ABSTRACT:

Background/objectives

The mediating role of eating behaviors in genetic susceptibility to weight gain during mid-adult life is not fully understood. This longitudinal study aims to help us understand contributions of genetic susceptibility and appetite to weight gain.

Subjects/methods

We followed the body-mass index (BMI) trajectories of 2464 adults from 45 to 65 years of age by measuring weight and height on four occasions at 5-year intervals. Genetic risk of obesity (gene risk score: GRS) was ascertained, comprising 92 BMI-associated single-nucleotide polymorphisms and split at a median (=high and low risk). At the baseline, the Eating Inventory was used to assess appetite-related traits of 'disinhibition', indicative of opportunistic eating or overeating and 'hunger' whic

SUBMITTER: Brunner EJ 

PROVIDER: S-EPMC8005371 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature