Six-month changes in ghrelin and glucagon-like peptide-1 with weight loss are unrelated to long-term weight regain in obese older adults.

ABSTRACT:

Background and objective

Weight loss (WL) and subsequent regain are complex physiologic processes, and our understanding of the hormonal changes associated with these processes continues to evolve. We aimed to examine the effects of behavioral WL on 6-month changes in ghrelin and GLP-1 and evaluate the effects of these changes in gut hormones on weight regain among older adults.

Subjects and methods

One hundred seventy-seven obese (BMI: 33.5 (3.5) kg/m²) older adults (66.9 ± 4.7 years, 71.2% female, 67.6% white) were randomized to WL (WL; n = 68), WL plus aerobic training (n = 79), or WL plus resistance training (n = 75) for 18 months. Ghrelin, GLP-1, power of food scale (PFS), and weight were measured at baseline, 6 months, and 18 months.

Results

There was

SUBMITTER: Rejeski JJ 

PROVIDER: S-EPMC8005376 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature