Simultaneous T₁ , T₂ , and T_1ρ relaxation mapping of the lower leg muscle with MR fingerprinting.

ABSTRACT:

Purpose

To develop a novel MR-fingerprinting (MRF) pulse sequence that is insensitive to B1+ and B₀ imperfections for simultaneous T₁ , T₂ , and T_1ρ relaxation mapping.

Methods

We implemented a totally balanced spin-lock (TB-SL) module to encode T_1ρ relaxation into an existing MRF framework that encoded T₁ and T₂ . The spin-lock module used two 180° pulses with compensatory phases to reduce T_1ρ sensitivity to B₁ and B₀ inhomogeneities. We compared T_1ρ measured using TB-SL MRF in Bloch simulations, model agar phantoms, and in vivo experiments to those with a self-compensated spin-lock preparation module (SC-SL). The TB-SL MRF repeatability was evaluated in

SUBMITTER: Sharafi A 

PROVIDER: S-EPMC8005468 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature