Long-Term Survival and Causes of Death in Children with Trisomy 21 After Congenital Heart Surgery.

ABSTRACT:

Objective

To evaluate long-term transplant-free survival and causes of death in the trisomy 21 (T21) population after surgery for congenital heart disease (CHD) in comparison with patients who are euploidic.

Study design

This is a retrospective cohort study from the Pediatric Cardiac Care Consortium, enriched with prospectively collected data from the National Death Index and the Organ Procurement and Transplantation Network for patients with sufficient direct identifiers. Kaplan-Meier survival plots were generated and multivariable Cox proportional hazards models were used to examine risk factors for mortality between patients with T21 and 1:1 matched patients with comparable CHD who are euploidic.

Results

A long-term survival analysis was completed for 3376 patients

SUBMITTER: Peterson JK 

PROVIDER: S-EPMC8005470 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature