Individual Magnetoencephalography Response Profiles to Short-Duration L-Dopa in Parkinson's Disease.

ABSTRACT: Clinical responses to dopamine replacement therapy for individuals with Parkinson's disease (PD) are often difficult to predict. We characterized changes in MDS-UPDRS motor factor scores resulting from a short-duration L-Dopa response (SDR), and investigated how the inter-subject clinical differences could be predicted from motor cortical magnetoencephalography (MEG). MDS-UPDRS motor factor scores and resting-state MEG recordings were collected during SDR from twenty individuals with a PD diagnosis. We used a novel subject-specific strategy based on linear support vector machines to quantify motor cortical oscillatory frequency profiles that best predicted medication state. Motor cortical profiles differed substantially across individuals and showed consistency across multiple data folds.

SUBMITTER: Pena E 

PROVIDER: S-EPMC8005574 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature