Current State and Future Directions of Genetics and Genomics of Endophytic Fungi for Bioprospecting Efforts.

ABSTRACT: The bioprospecting of secondary metabolites from endophytic fungi received great attention in the 1990s and 2000s, when the controversy around taxol production from Taxus spp. endophytes was at its height. Since then, hundreds of reports have described the isolation and characterization of putative secondary metabolites from endophytic fungi. However, only very few studies also report the genetic basis for these phenotypic observations. With low sequencing cost and fast sample turnaround, genetics- and genomics-based approaches have risen to become comprehensive approaches to study natural products from a wide-range of organisms, especially to elucidate underlying biosynthetic pathways. However, in the field of fungal endophyte biology, elucidation of biosynthetic pathways is still

SUBMITTER: Sagita R 

PROVIDER: S-EPMC8005728 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature