Targeted knockdown of the adenosine A_2A receptor by lipid NPs rescues the chemotaxis of head and neck cancer memory T cells.

ABSTRACT: In solid malignancies, including head and neck squamous cell carcinoma (HNSCC), the immunosuppressive molecule adenosine, which accumulates in the tumor, suppresses cytotoxic CD8⁺ T cell functions including chemotaxis and tumor infiltration. Adenosine functions through binding to the adenosine A_2A receptor (A_2AR) present on T cells. In order to increase T cell migration into the tumor, the negative effect of adenosine must be abrogated. Systemic drug treatments targeting A_2AR are available; however, they could lead to negative toxicities due to the broad expression of this receptor. Herein, we developed a lipid nanoparticle (NP)-based targeted delivery approach to knock down A_2AR in T cells in order to increase their chemotaxis in the

SUBMITTER: Newton HS 

PROVIDER: S-EPMC8005736 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature