Non-Syndromic Intellectual Disability and Its Pathways: A Long Noncoding RNA Perspective.

ABSTRACT: Non-syndromic intellectual disability (NS-ID or idiopathic) is a complex neurodevelopmental disorder that represents a global health issue. Although many efforts have been made to characterize it and distinguish it from syndromic intellectual disability (S-ID), the highly heterogeneous aspect of this disorder makes it difficult to understand its etiology. Long noncoding RNAs (lncRNAs) comprise a large group of transcripts that can act through various mechanisms and be involved in important neurodevelopmental processes. In this sense, comprehending the roles they play in this intricate context is a valuable way of getting new insights about how NS-ID can arise and develop. In this review, we attempt to bring together knowledge available in the literature about lncRNAs involved with molecula

SUBMITTER: Barros II 

PROVIDER: S-EPMC8005948 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature