Approaches to Identify and Characterise the Post-Transcriptional Roles of lncRNAs in Cancer.

ABSTRACT: It is becoming increasingly evident that the non-coding genome and transcriptome exert great influence over their coding counterparts through complex molecular interactions. Among non-coding RNAs (ncRNA), long non-coding RNAs (lncRNAs) in particular present increased potential to participate in dysregulation of post-transcriptional processes through both RNA and protein interactions. Since such processes can play key roles in contributing to cancer progression, it is desirable to continue expanding the search for lncRNAs impacting cancer through post-transcriptional mechanisms. The sheer diversity of mechanisms requires diverse resources and methods that have been developed and refined over the past decade. We provide an overview of computational resources as well as proven low-to-high thr

SUBMITTER: Carter JM 

PROVIDER: S-EPMC8005986 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature