Development of Triantennary N-Acetylgalactosamine Conjugates as Degraders for Extracellular Proteins.

ABSTRACT: Targeted protein degradation (TPD) technology has drawn significant attention from researchers in both academia and industry. It is rapidly evolved as a new therapeutic modality and also a useful chemical tool in selectively depleting various protein targets. As most efforts focus on cytosolic proteins using PROteolysis TArgeting Chimera (PROTAC), LYsosome TArgeting Chimera (LYTAC) recently emerged as a promising technology to deliver extracellular protein targets to lysosome for degradation through the cation-independent mannose-6-phosphate receptor (CI-M6PR). In this study, we exploited the potential of the asialoglycoprotein receptor (ASGPR), a lysosomal targeting receptor specifically expressed on liver cells, for the degradation of extracellular proteins including membrane proteins. T

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC8006166 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature