Fractalkine Is Linked to the Necrosome Pathway in Acute Pulmonary Inflammation.

ABSTRACT: Acute pulmonary inflammation affects over 10% of intensive care unit (ICU) patients and is associated with high mortality. Fractalkine (CX₃CL1) and its receptor, CX₃CR1, have been shown to affect pulmonary inflammation, but previous studies have focused on macrophages. In a murine model of acute pulmonary inflammation, we identified inflammatory hallmarks in C57BL/6J and CX₃CR1^-/- mice. Pulmonary inflammation was significantly enhanced in the CX₃CR1^-/- animals compared to the C57BL/6J animals, as assessed by microvascular permeability, polymorphonuclear neutrophil (PMN) migration into lung tissue and alveolar space. The CX₃CR1^-/- mice showed increased levels of apoptotic PMNs in the lungs, and further i

SUBMITTER: Ngamsri KC 

PROVIDER: S-EPMC8006293 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature