Progression of pediatric celiac disease from potential celiac disease to celiac disease: a retrospective cohort study.

ABSTRACT:

Background

A subset of patients with serology suggesting celiac disease have an initially negative biopsy but subsequently develop histopathologic celiac disease. Here we characterize patients with potential celiac disease who progress to celiac disease.

Methods

We performed a retrospective analysis of children (0-18 years of age) with biopsy-confirmed celiac disease seen at St. Louis Children's Hospital between 2013 and 2018.

Results

Three hundred sixteen of 327 (96%) children with biopsy-confirmed celiac disease were diagnosed on initial biopsy. The 11 children with potential celiac disease who progressed to celiac disease had lower anti-tissue transglutaminase (anti-TTG IgA) concentrations (2.4 (1.6-5) X upper limit of normal (ULN) vs. 6.41 (3.4-10.5) X ULN) at tim

SUBMITTER: Sakhuja S 

PROVIDER: S-EPMC8006356 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature