Mathematical Modeling and Simulation Provides Evidence for New Strategies of Ovarian Stimulation.

ABSTRACT: New approaches to ovarian stimulation protocols, such as luteal start, random start or double stimulation, allow for flexibility in ovarian stimulation at different phases of the menstrual cycle. It has been proposed that the success of these methods is based on the continuous growth of multiple cohorts ("waves") of follicles throughout the menstrual cycle which leads to the availability of ovarian follicles for ovarian controlled stimulation at several time points. Though several preliminary studies have been published, their scientific evidence has not been considered as being strong enough to integrate these results into routine clinical practice. This work aims at adding further scientific evidence about the efficiency of variable-start protocols and underpinning the theory of follicul

SUBMITTER: Fischer S 

PROVIDER: S-EPMC8006380 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature